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Technologies for Hemostasis and Stabilization of the Acute Traumatic Wound

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Technical Report,26 Sep 2013,25 Sep 2014

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University of Nebraska Medical Center Omaha

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The purpose of this research is to develop effective hemostatic devices for two difficult types of hemorrhage 1 traumatic noncompressible also known as truncal hemorrhage and 2 traumatic hemorrhage in the cold coagulopathic subject. The scope of this research will include both military and civilian trauma victims, particularly those suffering from hemorrhagic truncal injury andor coagulopathic hemorrhage. During the third year Y3 of this project, we continued to generate stocks of two clotting factors fibrinogen and Factor XIII needed for the development and manufacture of our hemostatic devices. In addition, we improved our prototypes to deliver foaming technology for the treatment of noncompressible hemorrhage. We performed efficacy testing of the dual fibrin sealant-alginate foam technology in our noncompressible model, and we currently are making modifications to both our model system and our foam technology to increase the resultant device utility. In Y4 we will continue to develop this foam technology for use in noncompressible hemorrhage. In addition, we will resume work on the treatments for cold coagulopathic hemorrhage with in vitro tensiometer studies, followed by in vivo studies in our cold coagulopathic porcine hemorrhage model.

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