Phospholipids as Biomarkers for Excessive Alcohol Use
Technical Report,15 Sep 2014,14 Sep 2015
Indiana University Indianapolis United States
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Our proposal is to determine the diagnostic utility of sphingomyelin SM and lysophosphatidylcholine LPC as the potential biomarkers to screen for excessive alcohol use EAU a rising epidemic reported to be as high as 40 among returning veterans. Drinking becomes excessive when it causes or elevates the risk for alcohol-related problems or complicates the management of other health problems. According to the NIHNIAAA, excessive drinking is defined as men who drink more than 4 standard drinks in a day or more than 14 per week and women who drink more than 3 drinks in a day or more than 7 per week. Non-civilian military personnel have been deployed in support of the war efforts in Afghanistan Operation Enduring Freedom, OEF and Iraq Operation Iraqi Freedom, OIF since September 11, 2001. These sustained combat operations have resulted in military personnel experiencing physical threat or actual injury during the deployment and difficult adjustments during post-deployment period. Negative life stress is a major contributor to the onset and exacerbation of EAU. Theprevalence of EAU is alarming, and the vigilance and action to identify veterans with EAU is of importance. The consequences of under detection of EAU, thus delayed intervention are serious because relative risk of alcohol-related health conditions such as cirrhosis, pancreatitis, and hepatocellular carcinoma, is increased with the amounts and duration of alcohol consumed per day. We hypothesize that alcohol consumption elevates a panel of serum phospholipids sphingomyelin, and lysophosphatidylcholines in proportion to the level of consumption in the past month.