DHHC3 Contributions to Breast Cancer
Technical Report,01 Sep 2013,31 Aug 2014
Childrens Hospital Corporation Boston, United States
Pagination or Media Count:
Protein palmitoylation, more accurately termed as protein S-acylation, is reversibly regulated by a group of Asp-His-His-CysDHHC motif-containing palmitoyl acyltransferases PATs and several acylprotein thioesterases APTs 1. Its primary function is to regulate the spatial cycling of proteins between different compartments of cells, and thus to modulate protein activity and stability as well as multiprotein complex formation 1. By developing and applying unbiased palmitoyl-proteomics technologies, we and others showed that many palmitoylated proteins are enriched in cholesterol-rich membrane microdomains such as lipid rafts and tetraspanin-enriched microdomains TEMs 2.
- Medicine and Medical Research