Accession Number:

AD1000362

Title:

DHHC3 Contributions to Breast Cancer

Descriptive Note:

Technical Report,01 Sep 2013,31 Aug 2014

Corporate Author:

Childrens Hospital Corporation Boston, United States

Personal Author(s):

Report Date:

2014-11-01

Pagination or Media Count:

13.0

Abstract:

Protein palmitoylation, more accurately termed as protein S-acylation, is reversibly regulated by a group of Asp-His-His-CysDHHC motif-containing palmitoyl acyltransferases PATs and several acylprotein thioesterases APTs 1. Its primary function is to regulate the spatial cycling of proteins between different compartments of cells, and thus to modulate protein activity and stability as well as multiprotein complex formation 1. By developing and applying unbiased palmitoyl-proteomics technologies, we and others showed that many palmitoylated proteins are enriched in cholesterol-rich membrane microdomains such as lipid rafts and tetraspanin-enriched microdomains TEMs 2.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE