New Methods of Low-Field Magnetic Resonance Imaging for Application to Traumatic Brain Injury
Technical Report,10 Jan 2014,09 Jan 2015
HARVARD UNIV CAMBRIDGE MA CAMBRIDGE
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We are developing robust low-magnetic-field implementations of MRI LFI focused on brain imaging with two complimentary test scanner systems electromagnet and permanent magnet based. We have also developing injury-sensitive MRI based on the detection of free radicals associated with injury using the Overhauser effect and subsequently imaging that modified nuclear polarization using low-field MRI OMRI. We have been optimizing imaging sequences, image reconstruction, and parallel imaging based acceleration in this unique regime. Results include demonstration of an optimized head coil for 3D human brain imaging in the electromagnet LFIat 6.5 mT, preliminary 3D imaging in a 100 lb scanner based on a rotating permanent magnet array, and improved free-radical OMRI both in vitro and in vivo. Application of the suite of techniques and technologies from our work could advise future development of a deployable device with a high diagnostic impact, transforming diagnosis and monitoring of secondary injury prevalent in TBI.
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