Endocannabinoids as a Target for the Treatment of Traumatic Brain Injury
Technical Report,04 Oct 2013,03 Oct 2014
LOUISIANA STATE UNIV NEW ORLEANS NEW ORLEANS
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The results from our ongoing studies during this funding period have provided evidence that EC enzyme degradation inhibitors are effecting at reducing astrocyte and microglial activation at 24hrs post-TBI. In addition, perfusion fixed brains with one dose of the EC enzyme degradation inhibitors at 7 and 30 day post-TBI will undergo immunostaining to evaluate the injury lesion size and detection of activation of astrocytes and microglia, as well as neuronal cell death and density. Finally, oxidative stress related mRNA and protein expression will be measured in samples obtained 72 hrs post-TBI following two doses of the ECenzyme degradation inhibitors.
- Medicine and Medical Research