Recombination and Transmission Studies with Influenza Virus.
Annual progress rept. 1 Jun 72-1 Aug 73,
MOUNT SINAI SCHOOL OF MEDICINE NEW YORK
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Studies during the past year can be categorized as directly related to influenza vaccine development and application, vaccine related basic research and studies of the basic virology of influenza virus. The use of genetic recombination for the rapid selection of high yielding vaccine strains developed in this laboratory has received continuing application during the past year, both in this laboratory and abroad. The high yielding X-31 strain used in earlier vaccines has now been replaced in most American vaccines by X-37 or X-37a which are high yielding variants of the so-called England mutant of the Hong Kong subtype. The emergence of a radically different influenza B virus in Hong Kong in early 1972 has prompted application of the same technique with the influenza B viruses and successful recombination of the mutant strain BHong Kong572 with old laboratory strain BLee40 to obtain a high yielding virus BX-1 antigenically identical with the new variant. This strain has been distributed by the Bureau of Biologics to manufacturers for consideration in forthcoming production of supplemental mono-specific influenza B vaccines. Author
- Medicine and Medical Research