Accession Number:

AD0903316

Title:

Sustained Protection against Superficial Bacterial and Fungal Infections by Topical Treatment

Descriptive Note:

Annual progress rept. 1 Sep 71-31 May 72

Corporate Author:

PENNSYLVANIA UNIV PHILADELPHIA

Report Date:

1972-08-01

Pagination or Media Count:

22.0

Abstract:

The feasibility of providing sustained protection of the skin against infection by common micro-organisms has been shown in previous reports. Some antimicrobial agents remain active and persistent on human skin. Neomycin reduces growth of the flora under occlusion at a dose of 0.4 micrograms per sq. cm. Neomycin, chloramphenicol and some other drugs will reduce the high numbers of organisms created by preocclusion. Experimental infections with Staphylococcus aureus on mildly traumatized skin have been extensively investigated. By delaying inoculation of the pathogen until 24 hours after injury a safe yet realistic infection can be produced. The requirements for a valid test of antibacterial action are still in doubt but the ability of the test to detect effective antibacterial action is not doubted. Similarly basic studies of the Candida albicans infection model have indicated the safety repeatability and practical value of this test. Infections with Pseudomonas can now be created but repeatability remains a problem. Author

Subject Categories:

  • Medical Facilities, Equipment and Supplies
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE