Accession Number:

AD0874484

Title:

Chronic Disabling Dermatoses

Descriptive Note:

Annual progress rept. 1 Jun 69-31 May 70

Corporate Author:

PENNSYLVANIA UNIV PHILADELPHIA

Report Date:

1970-09-01

Pagination or Media Count:

19.0

Abstract:

Free fatty acids FFA liberated from sebum have been implicated in the pathogenesis of acne. To determine the lipase producing organisms three studies were performed. In the first, the scalp was treated topically with neomycin to eliminate aerobic cocci. No change in the percentage of free fatty acids occurred. Next, subjects received oral demethylchlortetracycline to abolish C. acnes. Those subjects with high FFA responded with a 50 reduction. The third study used topical amphotericin B to reduce yeasts Pityrosporum and the values for FFA are now being determined. Quantitative bacteriology and Baird Parker classification of the cocci in acne comedones showed the numerical preponderance of C. acnes. The cocci were almost always SII. Athletes foot has been examined with reference to the total microflora. A method for sampling the 4th interspace has been tested. Bacteria play a considerable role in the clinical appearance and course of this basically fungal condition. Author

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE