Relative Toxicity of Candidate Mothproofing Uniform Impregnant Didecyl Dimethyl Ammonium Chloride Aliquat 203 Trade Mark.
Final rept. Oct 67-Oct 69,
ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
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The relative toxicity of a candidate uniform mothproofing impregnant didecyl dimethyl ammonium chloride Aliquat 203 was investigated using mice, rats, guinea pigs, rabbits and humans. The technical grade compound and aqueous solutions of 0.1 percent or greater caused primary skin irritation in rabbits. No primary skin or eye irritation in rabbits resulted from a single 24 hour application of a 0.01 percent aqueous solution. The skin irritating properties of Aliquat 203 in guinea pigs prevented the determination of the sensitization potential of this compound. Chronic ingestion of 800 ppm Aliquat 203 for 90 days caused minimal changes in rats. Cloth impregnated with 0.5 percent ww Aliquat 203 and applied continuously to the shaved skin of rabbits for 90 days produced no remarkable degree of skin irritation or evidence of potential toxicologic harzard. A prophetic patch test in humans of Aliquat 203 impregnated in wool fabric at a concentration of 0.5 percent by weight produced no evidence of skin irritation or sensitization. No data were developed which indicated that it would be hazardous to wear uniforms, for short periods of time, impregnated with 0.5 percent ww Aliquat 203. Author
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