Accession Number:

AD0855453

Title:

The Treatment of Shock Based Upon Physiological Principles and Impedance Method for Measuring Cardiac Output in Shock

Descriptive Note:

Annual progress rept. no. 5, 1 Jul 1968-30 Jun 1969

Corporate Author:

MINNESOTA UNIV MINNEAPOLIS

Report Date:

1969-07-25

Pagination or Media Count:

15.0

Abstract:

Using radioactive microspheres, we have found that neither endotoxin nor gram negative bacteria or the combination of the two, when used to induce shock in dogs, cause arteriovenous shunts to open in the gut or the liver. Shunts cannot be demonstrated in the lungs under these same conditions. Inflammation, in addition to injection of bacteria andor endotoxin appears necessary before arteriovenous shunts open. Capillary membrane permeability pressures in shock have been measured in the forepaw of the dog. Shock is associated with decreased capillary pressure due to leak of fluid through damaged capillary walls. Massive doses of corticosteroids or tolerance to shock induced with epinephrine or endotoxin preserves membrane permeability pressure in the normal range. Tolerance to epinephrine or endotoxin is also associated with decreased reactivity of the renal and intestinal microcirculation during shock. Correlation between laboratory experiments and clinical treatment of shock has been obtained with a portable shock unit. Author

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE