Nitrosoguanidine Mutagenesis and Chromosomal Replication in Staphylococcus Aureus
FORT DETRICK FREDERICK MD
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The number of mutations induced by nitrosoguanidine per 1,000,000 survivors is the same for exponential cells as for cells with resting, complete chromosomes. During synchronous chromosomal replication, no peak of mutations per million survivors appears at the time of duplication of the genes examined. It was concluded that for Staphylococcus aureus the replicating region of the chromosome is no more susceptible to nitrosoguanidine mutation than is the resting chromosome.