Interference Between the Vaccinal Virus and the Common Rabies Virus (Interference Entre le Virus Vaccinal et le Virus Rabique des Rues)
ARMY BIOLOGICAL LABS FREDERICK MD
Pagination or Media Count:
An interference between the vaccinal virus and the virus of rabies has been demonstrated using the rabbit. The method of inoculation for the vaccinal virus as well as for the rabies virus was the intradermal method and this method allowed the demonstration of interference the inoculation of vaccinal virus was made along the edges of a circle around the rabies virus inoculation. This interference is manifested only when the inoculation with vaccinal virus precedes inoculation with rabies virus by a number of hours. The protection exerted by the vaccinal virus against the rabies virus became complete when the inoculation with vaccinal virus preceded that with rabies virus by forty-eight hours. The protection was partial when the interval was reduced to twenty-four hours. One does not observe any protection of animals when the interval is reduced to one hour or if the inoculation with vaccinal virus occurs after that with rabies virus. The chronological circumstances which afford this protection are suggestive of an interference exercised by the vaccinal virus against the rabies virus.