Use of N-Acetylcolchamine as a Mitotic Poison
ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER CHARLOTTESVILLE VA
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The anti-mitotic activity of N-acetylcolchamine on Ehrlich ascites cancer cells has been studied in vivo in mice. It has been established that N-acetylcolchamine is an inhibitor of mitosis which, like colchicine, is able to block cell division at the stage of metaphase. Since N-acetylcolchamine is more readily available than colchicine, and is easily obtained in a chemically pure state by acetylation of colchamine, it is recommended for use in various biological studies in place of colchicine.