Accession Number:

AD0851843

Title:

Use of N-Acetylcolchamine as a Mitotic Poison

Descriptive Note:

Technical translation

Corporate Author:

ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER CHARLOTTESVILLE VA

Report Date:

1969-04-22

Pagination or Media Count:

11.0

Abstract:

The anti-mitotic activity of N-acetylcolchamine on Ehrlich ascites cancer cells has been studied in vivo in mice. It has been established that N-acetylcolchamine is an inhibitor of mitosis which, like colchicine, is able to block cell division at the stage of metaphase. Since N-acetylcolchamine is more readily available than colchicine, and is easily obtained in a chemically pure state by acetylation of colchamine, it is recommended for use in various biological studies in place of colchicine.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE