Note on the Synthesis of C-Toxiferin-I from Wieland-Gumlich-Aldehyde Comparison of Toxicity of Synthetic and Natural Curare-Alkaloids
ARMY BIOLOGICAL LABS FREDERICK MD
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A good preparative method is described to produce C-toxiferin-I from Wieland-Gumlich-aldehyde Selfcondensation of Nb-methyl-Wieland-Gumlich Aldehyde to C-toxiferin-I, diacetyl C-toxiferin-I, and Nb-dimethylcaracurin-V Conversion of Nb-dimethylcaracurin-V in the reaction mixture to C-toxiferin I, and diacetyl C-toxiferin I via toluensulfonic acid and in HAS Saponification of diacetyl-C-toxiferin I. The toxicity of the synthetic alkaloids C-toxiferin I, Nb-dimethylcaracurin-V, C-dihydro toxiferin, and dihydro toxiferin-I was tested and compared to the corresponding natural alkaloids. The toxicities of the synthetic and natural compounds were very similar.
- Organic Chemistry