On the Serological Specificity of Subunits of Two Arboviruses of Group A (Sindbis and WEE) (Ueber die Serologische Spezifitat von Untereinheiten Zweier Arboviren der Gruppe A (Sindbiss und WEE)
ARMY BIOLOGICAL LABS FREDERICK MD
Pagination or Media Count:
The serological specificity of four subunits of Sindbis and WEE virus was investigated in cross-reactions. The four subunits were complete virus particles, the hemagglutinin, and the so-called 1.300- and 1.345-cores. In neutralization studies, a uni-directional relationship between Sindbis and WEE virus was demonstrated, in which Sindbis antibodies neutralized Sindbis and WEE virus, whereas WEE antibodies reacted with the homologous virus only. An analogous relationship was also found in the CF reaction with 1.300- and 1.345 cores, especially with the latter. On the other hand, complete virus particles and hemagglutinin showed clear-cut cross-reactions when used in CF reactions. The results are discussed in relation to the antigenic structure of the two viruses and to the uni-directional relationship which has been demonstrated for certain subunits.