Effect of Formaldehyde on Staphylococcal Enterotoxin B: Immunogenic Activity in Macaca Mulatta
FORT DETRICK FREDERICK MD
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Monkeys were immunized with enterotoxin or enterotoxoid by intracutaneous injection or by feeding. Identical schedules were used in order to compare the effectiveness of the two antigens and the two routes. Enterotoxin administered intracutaneously was most effective oral administration of enterotoxoid was least effective. Intracutaneous injection of toxoid and oral feeding of toxin were intermediate and not too dissimilar from each other in effectiveness. Antibody titers and protection persisted for at least 1 year at a relatively high level. Monkeys that had preimmunization hemagglutinins showed an anamnestic response following immunization. The development of protection and the appearance of antibodies subsequent to feeding toxin or toxoid suggest that ingestion of food contaminated by staphylococci or their metabolites may be one cause for the appearance of antitoxin in the serum of supposedly unexposed animals and man.