Accession Number:

AD0848557

Title:

Insulin Effect

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1968-07-01

Pagination or Media Count:

5.0

Abstract:

The authors utilized the formation of the endogenous insulin during hyperglycemia, which was produced by the double glucose load according to Staub-Traugott, for the explanation of the interaction between insulin and alkaline phosphatase. Rabbits were used as experimental animals. It was shown that the activity of the alkaline phosphatase changed several times during the course of the experimentally produced hyperglycemia. One of these changes, namely the weakening of the activity, corresponds regularly to the formation phase of the hyperglycemia at which the effect of the insulin begins to show. The explanation of this action leads to the unquestionable conclusion that insulin inhibits the activity of the alkaline phosphatase. The authors still point out that the weakened effect of the blood phosphatase in the Gierke disease can be in a certain relation with the established inhibitory effect of the insulin.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE