Interference Among Group A Arboviruses
FORT DETRICK FREDERICK MD
Pagination or Media Count:
Interference among group A arboviruses that did not involve the mediation of interferon is described. Interference was observed only if the interfering virus had an advantage over the challenge virus either in time or in multiplicity of infection. Adsorption, penetration, and uncoating of challenge virus did not appear to be inhibited, but the synthesis of infectious viral RNA of the challenge virus was significantly retarded. With temperature-sensitive viruses or mutants, the replication of viral RNA by the interfering virus was required to establish interference. A mechanism of interference based on a competition for replication sites or substrates was compared with other possible explanations.