An Infectious Subtype of the Nature of Ribonucleic Acid from Brains of Mice Infected with Yellow Fever Virus
ARMY BIOLOGICAL LABS FREDERICK MD
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Ribonucleic acid, with a 0.03 infectiosity of the original virus, was obtained by phenol extraction from the brains of mice infected with yellow fever. The preparation displayed the UV absorption that is characteristic of nucleic acids. Protein admixtures were not detectable with the biuret test. Ribonuclease, trypsin and also serum globulin inhibited the infectiosity. Deoxyribonuclease, chymotrypsin and ethanol were without effect. The inhibitory action of trypsin is discussed.