Accession Number:

AD0843856

Title:

An Infectious Subtype of the Nature of Ribonucleic Acid from Brains of Mice Infected with Yellow Fever Virus

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

• Neilsen, G.
• Marquardt, J.

Report Date:

1963-12-01

Pagination or Media Count:

16.0

Abstract:

Ribonucleic acid, with a 0.03 infectiosity of the original virus, was obtained by phenol extraction from the brains of mice infected with yellow fever. The preparation displayed the UV absorption that is characteristic of nucleic acids. Protein admixtures were not detectable with the biuret test. Ribonuclease, trypsin and also serum globulin inhibited the infectiosity. Deoxyribonuclease, chymotrypsin and ethanol were without effect. The inhibitory action of trypsin is discussed.

Descriptors:

• *RIBONUCLEIC ACIDS
• *YELLOW FEVER VIRUS
• BRAIN
• ENZYMES
• TRANSLATIONS
• ABSORPTION SPECTRA
• INHIBITION
• AUSTRIA
• TISSUE EXTRACTS

Subject Categories:

• Biochemistry
• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE