An Evaluation of Vaccines and the Effectiveness of Vaccinations Against Typhoid Fever. 12. Agglutinative Antibodies in the Serums of Rabbits Immunized with Anti-Typhoid Vaccines
ARMY BIOLOGICAL LABS FREDERICK MD
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The paper presents the results of experiments made on rabbits immunized with four anti-typhoid vaccines. The level of the anticellular antibodies anti H, O and Vi was tested in the animals in accordance with the instructions given by the Department for the Standardization of Biological Preparations of the World Health Organization. Animals were therefore selected which before commencement of immunization either contained in their serum no natural antibodies directed against the typhoid-bacillus antigens or else showed activity in low dilutions. Two groups of rabbits of five each were immunized with each vaccine, the doses being appropriately chosen. The highest immunization activity was found in the acetone vaccine and minimum immunizing properties in the Westphal endotoxin. The Grasset-Slopek vaccine and the formol- phenol vaccine occupy an intermediate position, and their immunization values are of like order.
- Medicine and Medical Research