Accession Number:

AD0843833

Title:

An Evaluation of Vaccines and the Effectiveness of Vaccinations Against Typhoid Fever. 12. Agglutinative Antibodies in the Serums of Rabbits Immunized with Anti-Typhoid Vaccines

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

• Meislowa, Paula
• Rabczynska, Felicja
• Kudelski, Zygmunt

Report Date:

1964-01-01

Pagination or Media Count:

12.0

Abstract:

The paper presents the results of experiments made on rabbits immunized with four anti-typhoid vaccines. The level of the anticellular antibodies anti H, O and Vi was tested in the animals in accordance with the instructions given by the Department for the Standardization of Biological Preparations of the World Health Organization. Animals were therefore selected which before commencement of immunization either contained in their serum no natural antibodies directed against the typhoid-bacillus antigens or else showed activity in low dilutions. Two groups of rabbits of five each were immunized with each vaccine, the doses being appropriately chosen. The highest immunization activity was found in the acetone vaccine and minimum immunizing properties in the Westphal endotoxin. The Grasset-Slopek vaccine and the formol- phenol vaccine occupy an intermediate position, and their immunization values are of like order.

Descriptors:

• *SALMONELLA
• *VACCINES
• DOSAGE
• ANTIBODIES
• TRANSLATIONS
• RABBITS
• AGGLUTININS
• POLAND
• IMMUNE SERUMS
• IMMUNITY
• ANTIGENS

Subject Categories:

• Medicine and Medical Research
• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE