The Sensitivity of Guinea Pigs to Penicillin
ARMY BIOLOGICAL LABS FREDERICK MD
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The studies provide an insight into the significance of nutritive factors in the pathogenesis of toxic effects of penicillin. In practice, elimination of green fodder cauliflower leaves leads to a reduction in penicillin tolerance which is, however, not solely due to a lack of Vitamin C, since even manifold overdosage of ascorbic acid does not compensate the complex of toxic symptoms which develops through omission of green fodder. It can be surmised that cabbage leaves contain specific effective substances which are able to raise the limit of tolerance of guinea pigs towards penicillin. Tissue water deprivation caused by withdrawal of green fodder cannot in itself be decisive since the addition of fluids in the form of oatmeal gruel causes only a temporary increase in weight which is again followed by weight loss.
- Anatomy and Physiology