Accession Number:

AD0843483

Title:

The Sensitivity of Guinea Pigs to Penicillin

Descriptive Note:

Preliminary rept.

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

• Grimmer, H.

Report Date:

1967-10-20

Pagination or Media Count:

8.0

Abstract:

The studies provide an insight into the significance of nutritive factors in the pathogenesis of toxic effects of penicillin. In practice, elimination of green fodder cauliflower leaves leads to a reduction in penicillin tolerance which is, however, not solely due to a lack of Vitamin C, since even manifold overdosage of ascorbic acid does not compensate the complex of toxic symptoms which develops through omission of green fodder. It can be surmised that cabbage leaves contain specific effective substances which are able to raise the limit of tolerance of guinea pigs towards penicillin. Tissue water deprivation caused by withdrawal of green fodder cannot in itself be decisive since the addition of fluids in the form of oatmeal gruel causes only a temporary increase in weight which is again followed by weight loss.

Descriptors:

• *GUINEA PIGS
• EXPERIMENTAL DESIGN
• DOSAGE
• TRANSLATIONS
• DIET
• NUTRITION
• BODY WEIGHT
• WEST GERMANY
• PENICILLINS
• TOXIC TOLERANCES

Subject Categories:

• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE