ANTIDOTE ACTION OF BIS-(4-HYDROXYIMINOMETHYL PYRIDINIUM-(1)-METHYL)- ETHER DICHLORIDE IN RATS POISONED BY ALKYLPHOSPHATE
ARMY BIOLOGICAL LABS FREDERICK MD
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The antidote efficacy of bis-4-hydroxyiminomethyl pyridinium-1- methyl-ether dichloride LueH6, Toxogonin against alkylphosphate poisoning in rats was tested in vivo and in vitro. Paperchromatic analyses indicated the restoration of cholinesterase activity in the brain, serum and liver when LueH6 was used prophylactically after the rats were poisoned by 0,0-diethyl-p- nitrophenylphosphate Paraoxon and 0,0-diisopropylfluorophosphate DFP. The tolerance of LueH6 was 150 mgkg of body weight. The LD50 was 215 mgkg of body weight. Effective antidote activity was obtained by using 16th of the lethal dose. Within the limits of tolerance, no irreversible histological changes were observed.