SPECIFICITY OF ANTI-RNA ANTIBODIES (SPECIFICITE DES ANTICORPS ANTI-RNA)
ARMY BIOLOGICAL LABS FREDERICK MD
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The anti-RNA antibodies present in the sera of animals immunized with ribonucleoproteins ribosomes have been characterized as gamma-globulins. This character gamma-globulinic is also exhibited by the proteins gamma I precipitated by Poly I from human sera and from the sera of nonimmunized animals. The serum titer of these proteins gamma I increases with the age of the animal chicken and even much greater increases are found when animals are immunized with ribosomes. On the other hand, in sera containing antibodies to other antigens, the gamma I titer does not increase, but sometimes even diminishes as immunization is continued. From an anti-ribosomal horse serum, two broad categories of antibodies to RNA, a and b, exhibiting physico-chemical and immunological differences have been isolated. These fractions a and b interact with varying intensity with all of the polyribonucleotides and RNA used, but differ in their respective abilities of forming soluble or precipitating complexes with some of them. Their specificity is such that they react uniquely with polyribonucleotides and more specifically with the polyribose phosphate groups.