Accession Number:

AD0840531

Title:

IMMUNIZATION OF WHITE MICE TO ECTROMELIA WITH VACCINE VIRUS - II

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1968-04-24

Pagination or Media Count:

14.0

Abstract:

Intrapertioneal booster inoculation of vaccine virus strain Ankara renews immunization to induced intraperitoneal ectromelia infection. The protection of the booster shot becomes attenuated during the same interval of time as that of the initial vaccination, i.e. 12 to 26 weeks. Intraperitoneal administration of appropriate doses of commercially available vaccine lymph and or tissue-culture vaccine produces the same immunization to induced intraperitoneal ectromelia infection as the inoculum from vaccine strain Ankara infected chorio-allantois membranes. Intraperitoneal vaccination increases the survival rate of a stock of mice with latent ectromelia as against non-vaccinated controls of the same stock. Female mice develop a higher immunity than male animals.

Subject Categories:

  • Anatomy and Physiology
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE