OXYGEN CONSUMPTION OF THE ISOLATED PERFUSED LUNG LOBE OF THE DOG
FORT DETRICK FREDERICK MD
Pagination or Media Count:
The O2 consumption of the isolated dog lung lobe perfused with blood from a donor dog was investigated. The lung lobe had been made atelectatic and filled with Ringers solution. The arterio-venous O2 pressure difference was measured by polarography. The average O2 consumption of 11 lung lobes was 0.025 mlming of dry weight. There was no significant difference in O2 consumption between lung lobes perfused with arterial blood pO2 340-550 mm Hg and those perfused with venous blood pO2 55-90 mm Hg. Variation of the perfusion rate between 350 mlmin approx. normal value and 30 mlmin did not change the O2 consumption. Lowering the arterial blood pressure of the donor dog by hemorrhage had no effect upon the magnitude of the O2 consumption of the isolated lung lobe.
- Anatomy and Physiology