Accession Number:

AD0840033

Title:

ON THE CLINICAL APPLICATION OF A NEW ELECTROPHORESIS PROCESS IN LIVER DISEASES

Descriptive Note:

Corporate Author:

FORT DETRICK FREDERICK MD

Personal Author(s):

Report Date:

1968-07-01

Pagination or Media Count:

7.0

Abstract:

In increasing measure interest in medical-biological research has recently focused on the proteins of human serum and plasma. While the constituents of blood have been intensively studied for some time the difficulties of methodology have slowed the trend to use the analysis of proteins and peptides in clinical cases. There is obviously a need for a simple, reproducible instrument suitable for a larger series of experiments. The instrument should also be inexpensive. Such an instrument recently developed showed that amino acids and proteins can be separated on filter paper treated with a buffer solution. The proteins and amino acids may be made visible by staining. In carrying this principle further, this investigation focused on developing a dye which would stain proportionally to the concentration of the protein on paper. This together with a special method to quantitate the process of the electrophorotic separation is now described and shows great promise as a commonly useful, routine method to be used in hospitals and clinics.

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE