IMMUNITY OF WHITE MICE TO EEE VIRUS. REPORT NO. 7. FURTHER INVESTIGATIONS OF THE ROLE OF INTERFERENCE IN CEREBRAL IMMUNITY
ARMY BIOLOGICAL LABS FREDERICK MD
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An attempt is made to explain the resistance of EEE-immune mice to intracerebral challenge with VEE-virus serologically different from the EEE- virus on the basis of an interference phenomenon. When mice which had been passively immunized with homologous EEE-hyperimmune serum were shortly afterwards given intracranial experimental infection with a large dosage about .000001 LD of EEE-virus and eight or ten days later were given intracranial decimal solutions of VEE virus, a mutual interference was found between the two serologically different virus strains. While 80 of control animals not infected with VEE virus became ill at a later time from EEE, those which were given superinfections intracranially with .01 to .001 LD50 of VEE virus did not show any EEE illness at a later date. An autosterilization of the brain evidently took place in the absence of any specific antibodies. The significance of interference phenomena as a factor in immunity is discussed in connection with EEE and other animal virus diseases.
- Medicine and Medical Research