Accession Number:

AD0839358

Title:

ANTIMICROBIAN ACTIVITY OF CHLORPROMAZINE, ANTAGONISTIC ACTION OF ADENOSINE-5 TRIPHOSPHATE (ATP) AND SOME ELECTRONIC ASPECTS OF THOSE ACTIONS

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

• Trefouel, Jacques

Report Date:

1962-08-01

Pagination or Media Count:

5.0

Abstract:

A study was made of the antimicrobian activity of chlorpromazine, which theoretical chemistry calculations represent as a strong donor of electrons. The antagonistic action of adenosine-5 tiphosphate ATP was also shown. Its addition to a culture of staphylococci which had been arrested by chlorpromazyne makes possible the renewal of growth. The lyse of the same germ by an appropriate phage, decelerated by chlorpromazine, was accelerated by a simultaneous addition of biliverdin, a substance presenting the properties of a good acceptor of electrons.

Descriptors:

• *CHLORPROMAZINE
• FRANCE
• ADDITIVES
• TRANSLATIONS
• STAPHYLOCOCCUS
• GROWTH(PHYSIOLOGY)
• MOLECULAR ORBITALS
• CULTURE MEDIA
• ADENOSINE PHOSPHATES
• BACTERIOPHAGES
• BILE PIGMENTS

Subject Categories:

• Biochemistry
• Microbiology
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE