Accession Number:

AD0838829

Title:

SMALL PLAQUE MUTANTS OF THE SINDBIS VIRUS

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

• Hannoun, Cl.
• Asso, J.
• Ardoin, P.

Report Date:

1965-11-05

Pagination or Media Count:

9.0

Abstract:

In embryo cell cultures in gel medium infected with the Sindbis virus, two types of plaques appear large G and small p plaques. The G plaques appear in 24 hours and grow until they attain a diameter of more than 20mm. The small plaques p appear after 48 hours but never attain a diameter exceeding 3mm. After three successive reinoculations stable sub-lines of the p type are obtained, while the G sub-lines always give rise to a predominance of G but a small, constant percentage of p plaques. The interpretation of this phenomenon is that a mutation is spontaneously occurring, giving rise to small- plaque mutants from clones of wild-type, large-plaque viruses.

Descriptors:

• *ARBOVIRUSES
• MUTATIONS
• FRANCE
• TRANSLATIONS
• GROWTH(PHYSIOLOGY)
• CULTURE MEDIA
• MORPHOLOGY(BIOLOGY)

Subject Categories:

• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE