Accession Number:

AD0838555

Title:

INTRACELLULAR MULTIPLICATION IN RELATION TO VIRULENCE IN MACROPHAGE GUINEA-PIG CULTURES OF SHIGELLA FLEXNERI,

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

• Cefalu, M.
• Brancato, P.
• Saeli, M.

Report Date:

1966-01-25

Pagination or Media Count:

20.0

Abstract:

There is no significanct difference between these findings in tests with guinea-pig cells and those of Gerber and Watkins 1961 in their study of the course of a Shigella flexneri infection of a human cell strain the Henle strain, derived from embryonic intestinal epithelia. This means that the artificial laboratory conditions attendant upon tissue cultures in vitro banish numerous factors which are always present in the living specimen. This is further indication that Sh. flexneri and the Shigella group in general is preferentially parasitic upon man, and displays a positive tropism for intestinal tissue. Author

Descriptors:

• *SHIGELLA FLEXNERI
• VIABILITY
• PHAGOCYTES
• CULTURE MEDIA
• IN VITRO ANALYSIS
• INFECTIOUS DISEASES
• GROWTH(PHYSIOLOGY)
• ANTIGEN ANTIBODY REACTIONS
• RETICULOENDOTHELIAL SYSTEM
• AGGLUTININS
• ITALY

Subject Categories:

• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE