Accession Number:

AD0838554

Title:

STUDIES ON ARBORVIRUSES AND THEIR EXTRACTS BY MEANS OF CHROMATOGRAPHY ON ION-EXCHANGE CELLULOSES AND GEL-FILTRATION ON AGAROSE

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

• Nicoli, J.

Report Date:

1965-11-29

Pagination or Media Count:

17.0

Abstract:

Chromatography on ion exchange cellulose permits the separation of the virus studied. No soluble hemagglutinin has been found. Gel-filtration on agarose columns demonstrates a homogeneous behavior of infectious and hemagglutinating properties of the original preparations. Viral particles break when subjected to the action of ether and detergents the break is associated with loss of infectious capacity only hemagglutinating units obtained with this method preserve certain characteristics of the virions from which they are issued immunologic specificity, inactivation, characters. The significance of these findings for the virion architecture is discussed.

Descriptors:

• *ARBOVIRUSES
• FRANCE
• ETHERS
• TRANSLATIONS
• IMMUNE SERUMS
• INHIBITION
• VOLUMETRIC ANALYSIS
• ACETONES
• GELS
• LIPOPROTEINS
• ION EXCHANGE
• CHROMATOGRAPHIC ANALYSIS
• CULTURE MEDIA
• AGGLUTININS

Subject Categories:

• Biochemistry
• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE