STUDIES ON ARBORVIRUSES AND THEIR EXTRACTS BY MEANS OF CHROMATOGRAPHY ON ION-EXCHANGE CELLULOSES AND GEL-FILTRATION ON AGAROSE
ARMY BIOLOGICAL LABS FREDERICK MD
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Chromatography on ion exchange cellulose permits the separation of the virus studied. No soluble hemagglutinin has been found. Gel-filtration on agarose columns demonstrates a homogeneous behavior of infectious and hemagglutinating properties of the original preparations. Viral particles break when subjected to the action of ether and detergents the break is associated with loss of infectious capacity only hemagglutinating units obtained with this method preserve certain characteristics of the virions from which they are issued immunologic specificity, inactivation, characters. The significance of these findings for the virion architecture is discussed.