Accession Number:

AD0838464

Title:

ACTION OF CHLORPROMAZINE (CPZ) ON EXPERIMENTAL POISONING AND INFECTION OF MICE WITH P. PESTIS (VACCINAL EV STRAIN),

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

• Gallut, J.
• Girard, G.

Report Date:

1965-11-29

Pagination or Media Count:

6.0

Abstract:

Chlorpromazine increases the severity of the intoxication in mice experimentally inoculated with plague toxin. Cortisone has but a very weak action on this harmful effect. On the other hand, chlorpromazine does not prevent the enhancement of virulence induced by cortisone in Pasteurella pestis infection. These findings show that the drugs should not be used in the treatment of human plague. Author

Descriptors:

• *CHLORPROMAZINE
• TOXICITY
• YERSINIA PESTIS
• TOXINS AND ANTITOXINS
• CHEMOTHERAPEUTIC AGENTS
• VIABILITY
• INFECTIOUS DISEASES
• VACCINES
• FRANCE

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE