PRODUCTION OF A VARIANT OF ENCEPHALOMYELITIS VIRUS BY ITS ADAPTATION TO EXTRANEURAL TISSUE
ARMY BIOLOGICAL LABS FREDERICK MD
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When the adapted virus was subjected to several successive cerebral passages, it was shown that the properties newly acquired in the tissue culture were retained even under the original environmental conditions. Both this fact and the cytopathogenic effect suddenly arising after 9 blind passages support the assumption of a genotypical adaptation. The changed reactive norm of the genotype could be due to a previously extant mutant, a mutant accidentally developed during adaptation, or to segregation.