Accession Number:

AD0838274

Title:

PRODUCTION OF A VARIANT OF ENCEPHALOMYELITIS VIRUS BY ITS ADAPTATION TO EXTRANEURAL TISSUE

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

• Habermehl, K. O.
• Diefenthal, W.

Report Date:

1968-07-01

Pagination or Media Count:

14.0

Abstract:

When the adapted virus was subjected to several successive cerebral passages, it was shown that the properties newly acquired in the tissue culture were retained even under the original environmental conditions. Both this fact and the cytopathogenic effect suddenly arising after 9 blind passages support the assumption of a genotypical adaptation. The changed reactive norm of the genotype could be due to a previously extant mutant, a mutant accidentally developed during adaptation, or to segregation.

Descriptors:

• *ARBOVIRUSES
• BRAIN
• DISEASES
• MUTATIONS
• IN VITRO ANALYSIS
• DOSAGE
• TRANSLATIONS
• IMMUNE SERUMS
• IMMUNITY
• GERM CELLS
• MORPHOLOGY(BIOLOGY)
• IN VIVO ANALYSIS
• WEST GERMANY
• INJECTIONS(MEDICINE)
• PARALYSIS
• CULTURE MEDIA
• TISSUE CULTURE
• ADAPTATION(PHYSIOLOGY)

Subject Categories:

• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE