Accession Number:

AD0837175

Title:

THE DEVELOPMENT OF A LABORATORY MODEL FOR THE TRANSMISSION OF AFRICAN TRYPANOSOMIASIS,

Descriptive Note:

Corporate Author:

WALTER REED ARMY INST OF RESEARCH WASHINGTON DC

Personal Author(s):

• Ward, Ronald A.

Report Date:

1968-01-01

Pagination or Media Count:

11.0

Abstract:

Glossina austeni can be readily infected with the polymorphic trypanosome, T. brucei Lugala I using guinea pigs as donor and recipient hosts and lop-eared rabbits as maintenance hosts. The age of the fly at the time of the infective meal is the most important factor in successful laboratory infections. Day old flies had a midgut infection rate of 27 while less than 1 of the older flies became infected. 3 of day old flies developed salivary gland infections. A complete cyclical transmission of T. brucei was demonstrated. Sufficient replicates of the infection procedures have been performed to indicate that this system should be a useful model for the study of African trypanosomiasis. Author

Descriptors:

• *DISEASE VECTORS
• *TRYPANOSOMA
• DISEASES
• DIPTERA
• INFECTIOUS DISEASES
• SALIVARY GLANDS
• RODENTS
• AGING(PHYSIOLOGY)
• LABORATORY ANIMALS

Subject Categories:

• Animal Husbandry and Veterinary Medicine
• Anatomy and Physiology
• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE