Accession Number:

AD0837111

Title:

BIOCHEMICAL TOXICOLOGY OF CA, CS, AND CN

Descriptive Note:

Corporate Author:

EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Personal Author(s):

• CuCinell, Samuel A.
• Biskup, Ronald K.
• Loure, Stanton C.
• , Hubert L.
• Swentzel, Kipling C.

Report Date:

1968-01-01

Pagination or Media Count:

14.0

Abstract:

The lachrymator agents CA, CS and CN react in vitro and in vivo with biological anions. There is a definite relationship between the in vitro reactions of these agents and their toxicologic effects. In the body the CS- anion complex is further degraded to yield thiocyanate and organic residues. CS releases smooth muscle active substances from tissue not unlike bradykinin. CS aerosol produces a somewhat unique syndrome in dogs characterized by apnea followed by episodic hyperventilation, erythrocytosis, hypothermia, anoxia and acidosis. Recovery by these dogs even from high doses Cts is the rule.

Descriptors:

• *CHEMICAL WARFARE AGENTS
• AEROSOLS
• TOXICITY
• IN VITRO ANALYSIS
• ALKYLATION
• PATHOLOGY
• DETOXIFICATION
• THIOCYANATES
• CS AGENTS
• HYPERVENTILATION
• TEAR GAS
• ACIDOSIS
• ANOXIA
• BLOOD DISEASES
• RESPONSE(BIOLOGY)
• IN VIVO ANALYSIS
• ERYTHROCYTES
• HYPOTHERMIA

Subject Categories:

• Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE