BIOCHEMICAL TOXICOLOGY OF CA, CS, AND CN
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
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The lachrymator agents CA, CS and CN react in vitro and in vivo with biological anions. There is a definite relationship between the in vitro reactions of these agents and their toxicologic effects. In the body the CS- anion complex is further degraded to yield thiocyanate and organic residues. CS releases smooth muscle active substances from tissue not unlike bradykinin. CS aerosol produces a somewhat unique syndrome in dogs characterized by apnea followed by episodic hyperventilation, erythrocytosis, hypothermia, anoxia and acidosis. Recovery by these dogs even from high doses Cts is the rule.
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