Accession Number:

AD0836987

Title:

THE REACTIVITY OF TUBERCULOUS SKIN AREAS TO TUBERCULIN

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1964-08-13

Pagination or Media Count:

11.0

Abstract:

The specific tuberculous inflammation is developed by an allergic process as a result of apotoxin which is formed from the antigen and antibody. Differences in the intensity of the reaction can arise by a variation of the quantitative relationship between the antigen and the antibody. In freshly inflamed areas, no free antibody is present which could react with the new supply of antigen to form apotoxin, the cause of the inflammation. Following the decline of the inflammation, a local accumulation of antibodies remains. On this area of the skin, more antibody is present than in other, clinically normal, skin areas. This is the reason for the strong reaction of these areas to the introduced antigen. Furthermore, transitions between such extreme cases are also in existence where the primary inflammation is no longer at its peak but is already in a state of regression.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE