ADENOVIRUS INFECTIONS IN CHILDREN
FORT DETRICK FREDERICK MD
Pagination or Media Count:
All adenoviruses produce an antigen deviating the specific complement of the group. With the help of neutralization reactions and by inhibiting hemagglutination we may distinguish 28 types of adenoviruses. Clinically, the adenoviruses may produce acute and chronic infections. The acute infections are not quite well known and have been schematically presented in this report. The manifestations usually observed are 1 conjunctivitis, 2 pharyngo-conjunctival syndroms, 3 isolated pharyngitis, 4 atypical pneumonia without cold agglutinins, 5 morbilliform eruptions. Infantile pneumonia may in certain cases be accompanied by encephalic and renal manifestations. The evolution may be severe, sometimes fatal. Anatomic lesions are essentially pulmonary. In typical cases necrotic pneumonia with inclusions is involved. On the other hand, the chronic infections are little understood. In the first isolations of adenoviruses, it was demonstrated that these viruses may persist a long time in the organism in a latent state, particularly in the lymphoid tissues. The form and conditions of persistence of the virus in the tissues are not known. A recent study attributes a cancerous role in the baby hamster to adenovirus type 12.
- Medicine and Medical Research