ON THE INFLUENCE OF STAPHYLOCOCCUS TOXINS ON CELL CULTURES FROM MONKEY KIDNEYS
ARMY BIOLOGICAL LABS FREDERICK MD
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In the continuation of long-term studies on the mechanism of action of Staphylococcus toxins, a report is made on the influence of these substances on monkey kidney cell cultures. Crude filtrates of the laboratory strain SG 511 led to extensive break-up of the cell formations and change in form of the individual cells. Irrespective of their relatively high content of alpha-toxin, filtrates from the Wood 46 strain did not adversely affect either the growth or the structure of the cultures. Neutralization tests showed that the damaging effects to the cells that were observed are in no way related to the tested haemolyzing toxins. In the experimental lay-out used, the Staphylococcus enterotoxin possesses no cytopathogenic or cytotoxic action.