Accession Number:

AD0836180

Title:

RAPID ACTIVE IMMUNIZATION AGAINST TETANUS

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1963-12-30

Pagination or Media Count:

9.0

Abstract:

Two groups of 16-17 persons each were actively immunized against tetanus. The first group received two injections of 1.0 andor 0.5 ccm at an interval of 10 days. The second group received a total of 5 injections of 1.0 ccm initially and 0.5 ccm subsequently at intervals of 2 days each. The vaccine utilized was tetanol, control No. 44, of the Behring plants. The vaccine contained not less than 150 international units per ccm. Prior and up to the 129th day after start of vaccination, repeated determination of blood antitoxin was carried out six times in Group I and seven times in Group II. 0.005 IUccm serum are regarded as critical threshold value of the antitoxin concentration in the blood. The individuals of the first group reached andor exceeded this value prior to the 29th day after start of immunization. Only 5 of 16 individuals of this group had reached andor exceeded this value on the 19th day. 13 of the 17 individuals of Group II had reached or exceeded this value by the 19th day. The average antitoxin content in the blood of individuals of Group II was at least 15 times as high on the 19th day as that of the individuals of Group I and about 6 times as high on the 39th day.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE