Accession Number:

AD0836156

Title:

BEHAVIOR OF THE RETICULOENDOTHELIAL SYSTEM IN EXPERIMENTALLY-INDUCED ANTHRAX

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1964-03-19

Pagination or Media Count:

8.0

Abstract:

In a series of 35 experiments carried out on rabbits the author first sensitized the reticuloendothelial system by parenteral injection of colloidal substances silver, milk and iodine. The animals were subsequently inoculated with anthrax. It was noted that the state of allergy and resistance induced by the stimulating action on the reticuloendothelial system did not make itself felt against anthrax infection, while it seemed, instead, that the defensive powers reacted more ineffectively in sensitized animals than in control animals. It is believed that these results are attributable to the fact that the monocytosis induced by the stimulating action on the reticuloendothelial system represents a barrier which can easily be overcome by the infectious power of the anthrax germ so that these germs, resisting the phagocytal and bacteriolytic action of the monocytes, would be englobed by the monocytes, carried along by them and distributed throughout the body in a live state, thereby speeding up and aiding the actual spread of septicemia. Author

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE