Accession Number:
AD0836120
Title:
SYNTHESIS OF (N-METHYL-TYR)(2) OXYTOCIN,
Descriptive Note:
Corporate Author:
ARMY BIOLOGICAL LABS FREDERICK MD
Personal Author(s):
Report Date:
1963-09-01
Pagination or Media Count:
31.0
Abstract:
Different methods have been investigated for the preparation of N-CBO-S-bensyl-L-cysteinyl-N-methyl-L-tyrosyl-L-isoleucine. Condensation of the protected tripeptide with L-glytaminyl-L-asparaginyl-S-benzyl-L-cysteinyl-L-protyl-L-leucyl glycinamide affords N-CBO-S-benzyl-L-cysteinyl-N-methyl-tyrosyl L-isoleucul-L-glutaminyl-L-asparaginyl-S-benxyl-L-cysteinyl L-protyl-L-leucyl-gylcinamide. Cleavage of the protecting groups of the resulting nonapeptide with sodium in liquid ammonia, oxidation with air in dilute aqueous solution and purification by counter-current distribution gives the desired cyclic nonapeptide amide N-methyl-Tyr2-oxytocin. This exhibits less than one per cent of the oxytocic potency of oxytocin. Author
Descriptors:
Subject Categories:
- Biochemistry
- Pharmacology