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EXPERIENCES WITH THE THERAPEUTIC USE OF DIMETHYLSULFOXIDE IN ORTHOPEDICS
ARMY BIOLOGICAL LABS FREDERICK MD
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The percutaneous absorption of S35-labelled DMSO was studied in dogs. DMSO was very quickly absorbed after local application. The blood level reached a maximum in 20 minutes and remains constant at this level for 3-4 hours. Within 24 hours 35 of the total amount applied appeared in the urine. The distribution of DMSO in organs showed high accumulation of the activity in the skeletal muscle, and in the inner organ in the liver. DMSO was applied locally to 308 patients in an orthopedic-private practice. 100 cases of acute and chronic periarthritis were treated 83 cases of arthrosis of the knee, 30 patients with HWS-Syndrome, as well as 95 patients with various other acute and chronic illnesses of the muscles and skeletal systems. Single doses of 5-10 ml DMSO were applied daily. With acute cases periarthritis 2-3 applications daily were sometimes used during the first week of treatment. Of the total 308 cases, 27.6 obtained total relief, 53.6 were markedly improved and in 18.8 no effect was noted. In controls of clinical lab values red and white cell count, differential count, thrombocyte count, and serum transaminase activity a negative effect was noted after several months. Generally no side effects were noted which would have necessitated a curtailment of therapy.
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