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THE PART OF THE KIDNEYS, SUPRARENALS, AND SODIUM IN EXPERIMENTAL HYPERTENSION,
ARMY BIOLOGICAL LABS FREDERICK MD
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The report justifies the supposition that the regulatory mechanisms which maintain water and salt homeostasis are related to the mechanisms which maintain the circulatory homeostasis of the organism. At present, it is not clear by what method this relationship is established. Unquestionably, the relationship of the renin-angiotensin system to sodium metabolism, which concentrates its effect upon the suprarenal cortices, makes itself felt. Furthermore, mechanisms may participate which influence the course of active sodium transport, and thereby the value of the transmembranous sodium gradient which is probably in relation with the sensitiveness of vascular walls to vaso-effective impulses. From the present survey, it is evident that next to the kidneys whose role is unquestionable even though still not completely explained in the pathogenesis of hypertension, attention should be also paid to other factors. Among these, especially the study of those basic mechanisms stands out which determine the tonus and irritability of the smooth muscles of vessel walls in relation with the mechanism of active sodium transportation and its regulation. Author
APPROVED FOR PUBLIC RELEASE