Accession Number:

AD0835146

Title:

STUDY OF THE VARIABILITY OF THE TICK-BORNE VIRUS OF ENCEPHALITIS. REPORT 1. LONG CULTIVATION OF VIRUSES OF THE TICK-BORNE ENCEPHALITIS GROUP IN RENAL- CELL CULTURE OF PIG EMBRYO AND IN CHICK EMBRYOS

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

• Andzhaparidze, O. G.
• Stepanova, L. G.
• Bogomolova, N. N.
• Deciatskova, R. G.

Report Date:

1965-01-01

Pagination or Media Count:

7.0

Abstract:

As a result of the prolonged passaging in a culture of pig-embryo renal cells at 33C 70 passages and at 40C 80 passages, as well as in developing chick embroys 120 passages of the viruses of the tick-borne encephalitis group strains Ix-10, Pan, and I-40, the neuropathogenic properties of these strains for white mice have not been changed. As a result of the adaptation, certain strains have acquired the aptitude to destroy SOTs cells and fibroblasts of chick embryos. Pan and I-40 strains, both the initial and the variants obtained, have possessed the property to form plaques in culture of pig-embryo renal cells. Variants of the viruses, obtained at growing in cultures of pig-embryo renal cells at 40C Pan and I-40, at 33C, and in thick embryos I-40, have acquired the capacity to form plaques in cultures of SOTs cells.

Descriptors:

• *ARBOVIRUSES
• USSR
• TISSUE CULTURE CELLS
• DEGRADATION
• VIABILITY
• EMBRYONATED EGG TECHNIQUE
• TRANSLATIONS
• GROWTH(PHYSIOLOGY)
• TISSUE CULTURE
• ADAPTATION(PHYSIOLOGY)

Subject Categories:

• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE