PATHOGENESIS OF PLAGUE: II. AN EQUIVALENT OF THE GENERALIZED SHWARTZMAN REACTION IN THE MONKEY
FORT DETRICK FREDERICK MD
Pagination or Media Count:
Glomerular fibrin thrombi were observed in monkeys with both pneumonic and bubonic plague. Eighty per cent of animals in this study dying of pneumonic plague had glomerular thrombi. These findings are equivalent to those of the generalized Shwartzman reaction and suggest the possibility that endotoxin released from Pasteurella pestis during infection contributes to the pathogenesis of plague.
- Medicine and Medical Research