Accession Number:

AD0827092

Title:

PATHOGENESIS OF PLAGUE: II. AN EQUIVALENT OF THE GENERALIZED SHWARTZMAN REACTION IN THE MONKEY

Descriptive Note:

Corporate Author:

FORT DETRICK FREDERICK MD

Report Date:

1967-10-01

Pagination or Media Count:

18.0

Abstract:

Glomerular fibrin thrombi were observed in monkeys with both pneumonic and bubonic plague. Eighty per cent of animals in this study dying of pneumonic plague had glomerular thrombi. These findings are equivalent to those of the generalized Shwartzman reaction and suggest the possibility that endotoxin released from Pasteurella pestis during infection contributes to the pathogenesis of plague.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE