RELATIONSHIP OF EFFECTIVE DOSE TO BODY WEIGHT
Final rept. Aug 1964-Sep 1967
BIONETICS RESEARCH LABS INC FALLS CHURCH VA
Pagination or Media Count:
LD50s have been determined for tetrodotoxin, hemicholinium-3, d- tubocurarine, strychnine, alpha-naphthyl thiourea, 48-80 a histamine liberator , picrotoxin, sodium fluoroacetate, McN-A-343 a ganglionic stimulant, hexamethonium chloride, pentamethylene tetrazol, sodium pentobarbital, atropine, histamine, and sodium barbital by intraperitoneal injection into small, medium, and large male and female mice. Values have also been determined for histamine and alpha-naphthyl thiourea by intravenous injection. An attempt has been made to describe the relationship of toxicity to body weight for each of these instances. The most common dose to body weight relationship found is a direct linear one characterized by a slope of unity. However, a significant number of cases show a variety of other relationships, and preclude any over-all generalization. Experimental evidence is provided to demonstrate that the character of the relationship may vary with drug identity, route of administration, and sex of the test organism. There is no reason to expect that species, strain, and the other factors known to modify the intensity of drug action will not also modify the relationship of effective dose to body weight. The influence of each of these factors is, however, not predictable on the basis of present knowledge.