Accession Number:

AD0815217

Title:

EXPERIENCE ON MASS IMMUNIZATION OF HUMAN BEINGS WITH THE M-44 LIVE VACCINE AGAINST Q-FEVER. REPORT 2. SKIN AND ORAL ROUTES OF IMMUNIZATION

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1966-07-01

Pagination or Media Count:

10.0

Abstract:

With cutaneous application the live M-44 Q-fever vaccine turned out to be mildly reactogenic. The symptoms of a general reaction were weakly expressed and observed rarely 1.3. Based on immunological effectiveness the cutaneous method of vaccination with the live M-44 vaccine in the corresponding vaccine dose is not inferior to the subcutaneous method. Along with this it is a simpler method of immunization and this makes it possible to recommend the cutaneous live Q-fever vaccine for practical utilization in the mass inoculation of threatened contingents. Carrying out the mass immunization of human beings with the live Q-fever vaccine is possible without the preliminary selection based on serum immunological reactions. The results of the tests carried out on the harmlessness and immunological effectiveness of the live vaccine when it is administered by the oral route testify to the favorable outlook for putting into practice the oral application of the live Q-fever vaccine.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE