IN VIVO GROWTH AND DISTRIBUTION OF ANTHRAX BACILLI IN RESISTANT, SUSCEPTIBLE, AND IMMUNIZED HOSTS
FORT DETRICK FREDERICK MD
Pagination or Media Count:
In vivo growth curves of Bacillus anthracis in the body and various tissues in susceptible and resistant hosts have been developed. The effect of two levels of immunity imposed on these hosts was demonstrated. Differences in growth rates of organisms in the bodies of infected rats and guinea pigs showed the effect of innate resistance. As the degree of immunity was increased, the rate of organism buildup decreased and was accompanied by a decreased terminal population. The blood best reflected the population growth in the host. Data generated from the naturally resistant rat that had been immunized with both protective antigen and live vaccine demonstrated the role of toxins in terminal anthrax. Gross morphological studies pointed out the errors regarding terminal population of organisms when a sample was taken postmortem rather than at death.