Accession Number:

AD0813231

Title:

INACTIVATION OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS BY GAMMA RADIATION

Descriptive Note:

Corporate Author:

FORT DETRICK FREDERICK MD

Report Date:

1967-04-01

Pagination or Media Count:

14.0

Abstract:

Exposure of Venezuelan equine encephalomyelitis VEE virus at -70 C to 6,000,000 r gamma radiation Co60 resulted in loss of lethality for young adult mice and guinea pigs and loss of capacity to produce plaques or cytopathic effects in tissue culture. The suckling mouse was more sensitive for detecting live virus in irradiated suspensions than the adult mouse or guinea pig. Live virus was demonstrable in preparations exposed to 6,000,000 r but not in suspensions exposed to 8,000,000 r or more. The rate of inactivation of VEE virus by gamma radiation was an exponential function of the dosage.

Subject Categories:

  • Medicine and Medical Research
  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE