INACTIVATION OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS BY GAMMA RADIATION
FORT DETRICK FREDERICK MD
Pagination or Media Count:
Exposure of Venezuelan equine encephalomyelitis VEE virus at -70 C to 6,000,000 r gamma radiation Co60 resulted in loss of lethality for young adult mice and guinea pigs and loss of capacity to produce plaques or cytopathic effects in tissue culture. The suckling mouse was more sensitive for detecting live virus in irradiated suspensions than the adult mouse or guinea pig. Live virus was demonstrable in preparations exposed to 6,000,000 r but not in suspensions exposed to 8,000,000 r or more. The rate of inactivation of VEE virus by gamma radiation was an exponential function of the dosage.
- Medicine and Medical Research