NEUROLOGICAL AND PHYSIOLOGICAL RESPONSES OF THE PRIMATE TO ANTHRAX TOXIN
FORT DETRICK FREDERICK MD
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Anthrax toxin depressed the cerebral cortical electrical activity of both anesthetized and non anesthetized monkeys and anesthetized chimpanzees. Recordings on a physiograph recorder revealed changes in electrocardiogram and hypoxic hypertension that progressed with the degree of intoxication to final cardiovascular collapse. Changes in cortical electrical activity were either partial or complete, and in some cases cortical activity was depressed in cyclic patterns that appeared independent of other observed physiological changes. Subcortical changes in electrical activity occurred simultaneously with the surface cortical changes. The protective antigen component of the toxin alone caused the initial changes in surface cortical activity. Those animals that died showed a respiratory failure that appeared to be of central nervous system origin involving the respiratory center of the brain. Survival with no changes in physiological or cortical electrical activity occurred in monkeys pretreated 30 min or postreated up to 8 hours with specific antiserum.
- Anatomy and Physiology